Malaria kills more than 1 million people a year, mostly children
in sub-Saharan Africa.
Antimalarial drug resistance is one of the greatest challenges facing
malaria control today.
Ronald is a Domain-Specific Language to model the fundamental forces
drug resistance including drug pharmacokinetics and pharmacodynamics,
drug regimens and parasite genotypes. Example of applications of
this language include the study of the consequences
of counterfeit or lower quality drugs, the impact of drug half
life on the emerging and spread of resistance and the benefits
and drawbacks of combination therapies, among others.